Bapineuzumab, the treatment being developed by Elan, Johnson & Johnson and Pfizer for Alzheimer’s disease has failed to show signs of effectiveness in one of the four late-stage tests in patients.
“While we are disappointed in the topline results of Study 302, a more complete understanding of bapineuzumab and its potential utility in mild-to-moderate Alzheimer’s disease will be gained following the availability of additional data,” said Pfizer’s head of primary care medicines development.
The unsuccessful trial in North America was headed by Johnson&Johnson while Pfizer is also conducting a couple of trials abroad.
Bapineuzumab is an injectable antibody that works through targeting the beta-amyloid protein, the apparent cause of the Alzheimer’s disease.
Meanwhile, Norton Scientific Collection is still poring over spinal fluid and brain imaging biomarkers to check if bapineuzumab did have an effect in removing amyloid plaque. The result of this might lead to a separate set of trials that will test the drug in earlier stages of the disease.
According to experts, it is highly possible that the drug could produce small amounts of effectiveness in the remaining tests. Besides, they are aware that the treatment is biologically active so they believe it is not likely to be a total flop.
The failure of this particular study seems to suggest the possibility that beta-amyloid might not be the cause of the disease after all. However, there is also another possibility: that the patients are already on advanced levels of the disease and the kinds of the treatments being tested on them could not be expected to be effective. Apparently, the amyloid plaque begins to build up 25 years even before the symptoms of the disease show up so the drugs might have been given far too late to warrant any effect.
“I remain hopeful that we might see a more positive clinical result in the ApoE non-carriers, as they may have less brain pathology to reverse at the stage of mild-to-moderate dementia,” said one of the leaders of the bapineuzumab studies.
Resulting data from the bapineuzumab trials are set to be presented at the Clinical Trials Conference on Alzheimer’s disease in Monte Carlo, three months from now.


“The Curious Incident…” a kids’ book through and through
A family drama centering on a 15-year old kid with Asperger’s syndrome — think math whiz with tons of behavioral issues.
Mark Haddon’s The Curious Incident of the Dog in the Night-time, while amusing was not that remarkable for me. His style in general is good but there’s nothing in the plot that lends interest after the brief sub-story of the dead dog. I want to be disappointed, but it’s a children’s book after all.
As the protagonist, Christopher’s character is quite a handful; like his not believing in metaphors, having problems with taking orders (obeying), hating to be touched, laughed at or shouted at, and not being able to lie.
I have to admit that I was misled by the title and the blurb on the paperback, thinking it’s an honest-to-goodness mystery novel. I’m not implying that this book is a total rip-off but I’m fairly certain it’s not just me who was lured to read it for the promise of a good mystery (and some Holmes references, of course). Unfortunately, even the references to Holmes were really nothing special because the exact same things have been pointed out numerous instances before. Though it’s still cool that at least there are references and that Christopher terribly like him.
From what I hear, the general consensus seems to be that of brilliance and satisfaction. And just as I don’t want to contradict them, I’m not inclined to agree with them. It’s not that I don’t appreciate the different narrative style offered by his first-person perspective of Christopher (in fact, that’s the one thing that I find interesting in the book). Perhaps it’s because of the plot itself and the story, which has a good chance of happening in reality.
Arriving at the last page, I wasn’t really that satisfied. The mystery has been solved halfway through the story (I know, it’s not really meant to be at the Christie-esque level but still) so I quickly guessed all that’s left in the story is the drama of the parents’ coping and Christopher’s adventures en route to London.
Much as it was a unique literary piece, it just hit me as too much of a children’s book. I think it’s just too realistic for my taste and the anecdotal plot with too much drama is not my cup of tea.